When sexual stimulation triggers neighborhood release of NO, inhibition of PDE5 by sildenafil causes improved levels of cGMP during the corpus cavernosum, leading to clean muscle rest and inflow of blood to the corpus cavernosum. Sildenafil at proposed doses has no effect inside the absence of sexual stimulation.

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The physiologic system of erection of the penis includes launch of nitric oxide (NO) within the corpus cavernosum through sexual stimulation.

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